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She received her undergraduate instruction at Mt Holyoke Seminary (now a college) in 1871. She received degrees by examination from Syracuse University (a Ph.B. in 1888 and a Ph.D. in 1889) and also studied at the University of Chicago, receiving a Ph.D. in 1896. She became a professor of zoology at Mt. Holyoke College and was active in the research group at the then newly established (1888) Marine Biology Lab at Woods Hole, Massachusetts.
More can be found in Women at the Marine Biology Lab including a short bio with photo and a group photo with Clapp and others.
In addition, some of her papers are in the Archives and Special Collections at Mt Holyoke College.